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"Then what he would do is kill the rats and look at their organs." What was interesting to Selye was that no matter how different the tortures he devised for the rats were from icy winds to painful injections when he cut them open to examine their guts it appeared that the physical effects of his different tortures were always the same

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To trace smooth muscle cells, we used Sm22a CreERT2 or Myh11 CreERT2 mice and crossed them with Rosa26-tdTomato reporter alleles (hereafter referred to as Sm22a CreERT2