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Factors That May Affect Appropriateness According to general clinical guidance referenced in published sources, growth hormone secretagogues may not be appropriate for individuals with certain contraindications including active malignancies, uncontrolled diabetes, or other conditions that a clinician would evaluate during the prescribing process

Type 2 diabetes is characterized by insulin resistance

During this process, GSK3 is a downstream target of insulin-activated signaling and is an important enzyme involved in the control of glycogen metabolism [48]

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