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An increase in the flow of Ca 2+ is necessary for signal transduction, the formation of immune synapses, and the implementation of specific cytotoxicity of CD8 + T cells, which involves the costimulatory molecule of the cell surface LFA-1 and Mg 2+ (129)

Spironolactone, pregnenolone 16a-carbonitrile, and other xenobiotics also act by binding PXR, with results similar to cyproterone acetate (Kliewer 2003

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Dopaminergic signaling plays a central role in working memory, motivation, and goal-directed behavior