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Our findings suggest for the first time that TNC microglial GLP-1R activation suppresses the central sensitization of CM and that GLP-1R may serve as a new target for treating CM

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Pharmacokinetics: Long acting (half life: ~1 week ) Ozempic & Wegovy : subcutaneous pen injections weekly a more favorable option for some patients compared to daily injections of short acting analogs semaglutide has a high bioavailability of ~89% when injected s.c