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Who Should Consider Alternative Formulations or Dosing Strategies Patients with a history of severe nausea, vomiting disorders (like cyclic vomiting syndrome), concurrent gastrointestinal conditions (GERD, gastroparesis), or those taking medications that increase nausea risk may benefit from slower escalation protocols or alternative GLP-1 agents

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FIGURE 1 3.2 Semaglutide reduces I/R myocardial injury and promotes cardiac function recovery The cellular results informed the adoption of a MIRI mouse model to investigate semaglutides impact on cardiac function