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A similar trend was observed in REWIND, where sustained benefits emerged with extended treatment exposure, suggesting that younger people, by virtue of prolonged therapy duration, may accrue a greater cumulative benefit from GLP-1 RAs [41], potentially explaining the more marked death reduction observed in this subgroup within our study

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doi: 10.1016/j.sjbs.2020.05.018 115 PonnampalamENKianiASanthiravelSHolmanBWBLauridsenCDunsheaFR

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