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As these dosing schedules are recommended off-label, no clinical trials have been conducted on biweekly dosing of semaglutide, and long-term safety remains unknown

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The primary safety consideration with PT-141 is that it should not be administered to subjects with unmanaged high blood pressure or cardiovascular conditions [17]

One-way ANOVA showed significant differences between the groups in terms of age ( p = 0.001), hence age was included as a covariate in between group comparisons of metabolite concentrations