However, adrenergic activation of WAT lipolysis is essential to provide fatty acid substrates (especially acylcarnitines subsequently generated in the liver) to fuel BAT thermogenesis 35 , as well as skeletal muscle shivering thermogenesis under conditions of impaired BAT thermogenic activity
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Patients should receive clear written and verbal information about: Expected side effects of each medication Warning signs requiring immediate medical attention (severe abdominal pain, persistent vomiting, signs of pancreatitis, mood changes, suicidal thoughts) The importance of adherence to prescribed doses Lifestyle modifications to support treatment goals Multidisciplinary coordination may be beneficial, particularly when care involves both smoking cessation services and weight management clinics
Pistone G, Marino A, Leotta C, Dell'Arte S, Finocchiaro G, Malaguarnera M
