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Interestingly, two thirds of such replacements are in highly and moderately conserved (50% to 99%) amino acids, and relatively few are in fully conserved amino acids (where they might be lethal) or in poorly conserved amino acids, where presumably they simply would not cause G6PD deficiency

Vasoconstrictors, mainly midodrine (at an initial dose of 2.5 mg/die which may be weekly raised up to 30 mg/day), are second-line alternatives and could represent a preferred choice in JHS/EDS-HT in consideration of the increased risk of osteopenia/porosis

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Of these scenarios with various thresholds of the education attainment and data completeness inclusion criterion, we investigated two scenarios compared to the standard CY 2026 GPCI: (1) occupation codes with at least 75 percent of Bachelor's Degree or Higher excluding Group 29 and wage data for at least 50 percent of U.S