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Making it an ideal choice for athletes and fitness enthusiasts.

Complete immobilization produces weak, disorganized repair tissue while progressive loading promotes strong, aligned structures

Proposed Mechanisms Preventing GABA receptor downregulation Counteracting compensatory NMDA glutamate receptor sensitization Stabilizing benzodiazepine receptor configuration (preventing shift to inverse agonist state) Upregulating GABAergic neurotransmission through pathways distinct from benzodiazepine action itself This tolerance prevention has profound clinical implications

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