Pregnant or breastfeeding women should not use AOD-9604 due to lack of safety data in these populations
Anaphylactic reactions, which are severe allergic reactions that require immediate medical attention and can be life-threatening, with symptoms including chest tightness, itching, rash, trouble swallowing, swelling of the hands, face, or mouth, and trouble breathing
These attacks can be spontaneous or triggered by everyday actions such as chewing, speaking, touching the face, or brushing the teeth
The mechanistic rationale builds on earlier work by Kraus and colleagues in Nature (2014), in which adipocyte-specific NNMT knockdown protected mice from diet-induced obesity, establishing NNMT as a metabolic-disease target candidate [2]