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NICE recommends that: Pharmacological treatment should only be used as part of a comprehensive weight management programme Medications should be prescribed only when licensed and evidence-based Very low-calorie diets (VLCDs, 800 kcal/day) may be considered for specific patients under specialist supervision, but should be time-limited and nutritionally complete Wegovy is recommended by NICE (TA875) for specific patient groups: adults with a BMI of at least 35 kg/m (or 30 kg/m with weight-related comorbidities), who have at least one weight-related comorbidity and have completed a tier 3 service

P = 0.95), TC (SMD: 0.086

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