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The underlying mechanisms for increased HR remain to be fully elucidated, but may be related to a direct GLP-1 receptor effect on myocytes in the sinoatrial node of the human heart and/or stimulation of the sympathetic nervous system

Biochem Biophys Res Commun 74(4):15821588

reported that the apparent permeability coefficient (Papp) of the pegylated formulation was 3.04 10 4 cm min 1 , significantly higher than that of plain liposomes (2.17 10 4 cm min 1 ) and drug suspensions (0.9 10 4 cm min 1 ), indicating that PEG facilitates liposome penetration through the mucus layer and promotes transintestinal wall transport