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A 2006 Achilles-detachment study by Krivic and colleagues in the same journal applied BPC-157 intraperitoneally once daily at 10 g/kg, 10 ng/kg, or 10 pg/kg for 30 days in rats and reported that tendon-to-bone tissue, which did not heal spontaneously in saline controls, recovered with BPC-157 treatment, with directionally improved load-to-failure, stiffness, Young's modulus, and collagen organization at days 121, including in animals where healing had been impaired by 1 mg/kg 6-methylprednisolone though the abstract does not report numeric effect sizes or p-values

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BPC-157 is described as a stable pentadecapeptide studied in models of tissue repair, fibroblast activity and nitric oxide-related mechanisms, while TB-500 relates to the research area of thymosin beta-4, an actin-binding peptide involved in cell migration processes

2026;19(2):e70305